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Duchess Meghan turns 40: Prince Harry cameos in sweet birthday video, along with Melissa McCarthy

Duchess Meghan is going to have a royal good time for her 40th birthday.

The Duchess of Sussex said goodbye to her thirties and officially ushered in her forties on Wednesday doing what she loves best – giving back to others.

To celebrate, Meghan launched "40x40," her latest Archewell initiative aimed at pushing for people around the world to dedicate 40 minutes to support women's return to the workforce. 

The duchess tapped 40 influential women, including Stella McCartney, Adele, Amanda Gorman and Melissa McCarthy — who star in the announcement video — to spend time mentoring women in their communities.

The playful clip released on the Archewell Foundation website Wednesday includes McCarthy asking Meghan about her birthday plans over a video call, along with a sweet cameo appearance from Prince Harry.

"Over 2 million women in the U.S. alone and tens of millions around the world have lost their jobs due to COVID, and I think if we all do it and all commit 40 minutes to some sort of act of service, we can create a ripple effect," the duchess said in the video.

Duchess Meghan, who turns 40 on Aug. 4, has accomplished a lot in her thirties, blossoming from an American actress in the TV legal drama "Suits" to a global trailblazer.

Why 'Archewell'?: Duchess Meghan, Prince Harry explain name of new non-profit

After McCarthy suggests an alternative plan of "afternoon tea with the chickens," the two laugh when they spot Prince Harry outside, attempting and failing to juggle.

This mentorship initiative is "one way to help women regain confidence and rebuild their economic strength," a press release on the initiative reads.

Members of the royal family also acknowledged her milestone birthday from their social media accounts Wednesday. 

"Wishing The Duchess of Sussex a very Happy Birthday today," @theroyalfamily account, which represents Queen Elizabeth II, posted on Twitter along with three photos of the duchess with Harry, Archie and the queen. 

Prince William and Duchess Kate also posted Meghan on her special day to send birthday wishes using a photo of her on the beach: "Wishing a happy birthday to the Duchess of Sussex!"

It's become somewhat of a tradition for the Sussexes to commemorate personal celebrations with a charitable act, like building a new community relief center in Mumbai, India to mark their third wedding anniversary in May. 

New kind of royals:On third anniversary, Harry and Meghan embrace revolutionized royal roles

Born Rachel Meghan Markle on August 4, 1981, in Los Angeles, California, the duchess has accomplished a lot.

In the last decade, she has blossomed from an American actress to a global trailblazer that has harnessed the world's attention to drive change and promote compassion.  

The royal wedding, leaving 'Suits,' and motherhood: Duchess Meghan's 'liberating' thirties

Meghan had a successful career in Hollywood. She's best known for playing Rachel Zane on USA Network's legal drama "Suits" for seven seasons, beginning in 2011, before retiring from acting following her engagement to Prince Harry in November 2017.

"I don’t see it as giving anything up," she said during the couple's first joint interview with the BBC in 2017. "I just see it as a change. It’s a new chapter."

After dating for more than two years, Meghan and Prince Harry tied the knot on May 19, 2018, in a lavish royal wedding at Windsor Castle, becoming the Duchess of Sussex, Britain's first American and biracial royal couple. 

Nearly a year later, the couple welcomed their first child, son Archie Harrison Mountbatten-Windsor, on May 6, 2019, at Portland Hospital in London. His surname, Mountbatten-Windsor, is a tribute to his great-grandparents Queen Elizabeth II and the late Prince Philip, whose surname was Mountbatten. Archie is seventh in line to the throne.

Duchess Meghan welcomed her second child, daughter Lilibet 'Lili' Diana Mountbatten-Windsor, on June 4 at Santa Barbara Cottage Hospital in California. She's named after Queen Elizabeth II, whose nickname among family is "Lilibet." And her middle name, Diana, was chosen to honor her late grandmother, who died in a Paris car wreck in 1997.

Duchess Meghan'sroyal baby is here and it's a boy, Buckingham Palace says

Meghan, Harry welcome second child, named after Queen Elizabeth, Princess Diana

Duchess Meghan and Prince Harry welcomed their second child, daughter Lilibet 'Lili' Diana Mountbatten-Windsor, on June 4, 2021.

The period between giving birth to Archie and Lilibet marked major changes and defining moments for Meghan, who has revolutionized what it means to be a royal alongside Prince Harry. 

After years of intense scrutiny from the British tabloids, privacy concerns and allegations of racism in the royal family, Duchess Meghan and Prince Harry stepped back from their role as senior members of the royal family in an unprecedented move in March 2020.

The couple moved from Britain to Los Angeles, Meghan's hometown, to not only reinvent themselves but to speak out in a way no British royal has done before. 

In March, Duchess Meghan and Prince Harry sat down with Oprah Winfrey for a bombshell interview, the first since leaving their royal roles. 

Among the many revelations, the Sussexes said someone in the royal family (neither the queen nor Prince Philip) raised concerns about "how dark" Archie's skin might be at birth. Meghan also revealed she became suicidal from the pressures of royal life. 

"It's really liberating to have the right and the privilege in some ways to be able to say, 'yes, I'm ready to talk,'" Meghan told Winfrey. "To be able to just make a choice on your own and just be able to speak for yourself."

Meghan Markle on motherhood:New moms and women everywhere are thanking Duchess Meghan for saying she's not OK

Archewell efforts give a glimpse into what's next for Meghan Markle

Duchess Meghan moved back to the United States with her family to build a new life and become financially independent, free from royal constraints, and they're doing so through commercial endeavors and Hollywood partnerships. 

Duchess Meghan continues to redefine her life's trajectory – now through Archewell, the organization she founded in 2020 alongside Prince Harry.

According to the organization's official website, Archewell is a compound of "Arche," a Greek word meaning "source of action," and "well," a plentiful source or supply and a place we go to dig deep – the perfect description of Duchess Meghan's evolution as a businesswoman. 

Oprah Winfrey interviews Prince Harry and Meghan Markle on A CBS Primetime Special aired March 7, 2021.

Duchess Meghan and Prince Harry's organization is comprised of three separate divisions: Archewell Foundation, Archewell Productions and Archewell Audio. 

The royals signed a multiyear deal with Netflix in September to produce a scripted series, docu-series, documentaries, features and children’s programming. 

In April, they released their first Netflix docu-series "Heart of Invictus" and announced a second project in July, an animated series helmed by Duchess Meghan called "Pearl."

"Like many girls her age, our heroine Pearl is on a journey of self-discovery as she tries to overcome life’s daily challenges," said Meghan, who will serve as an executive producer. "I’m thrilled that Archewell Productions, partnered with the powerhouse platform of Netflix, and these incredible producers, will together bring you this new animated series, which celebrates extraordinary women throughout history."

Harry and Meghan release first podcast under Spotify with a special Archie moment

Netflix's new animated series 'Pearl,' created by Meghan and Harry, in development

The Duke and Duchess' media empire includes a multi-year deal with Spotify to produce podcasts and a slew of books, including Meghan's children's book called "The Bench," a USA TODAY best-seller, which features her husband and their son, Archie. It's based on a poem she wrote for Harry after Archie was born.

Contributing: Maria Puente, Elise Brisco USA TODAY; The Associated Press