Art

"Sanctum." A collection of internationally based artists, including Beili Liu and Scott Vincent Campbell, presents work based around the concept of genetic memory — how we inherit not only DNA but fear, habits, triumph, trauma and love, among other things, from our ancestors. A mixture of video, installation, photography, painting and sculpture, this group of work includes an excerpt from curator Alyssa Taylor Wendt’s latest film, "The Memory Inheritance," filmed recently in Detroit. Noon to 6 pm. Tuesday-Friday through Oct. 5. Big Medium, 916 Springdale Road, Building 2, No. 101. 512-939-6665, bigmedium.org

Nightlife

Hell Yes Project: APA Long-Stay Spotlight and Thrift Store Cleanup. The primary focus of the ABGB's partnership with Austin Pets Alive is to help find homes for the nonprofit's long-stay dogs. (These are dogs who have been with the shelter for more than 300 days.) At this Hell Yes Project, work a 90-minute shift at APA's thrift store before heading across the railroad tracks to the brewpub for some pizza and beer. 6 p.m. Sept. 10. Free. 1409 and 1305 W. Oltorf St. theabgb.com/event/hell-yes-project-apa-spotlight-thrift-store-cleanup

Coming up

9/11 Memorial Stair Climb at the Hill Country Galleria. Cheer on the Bee Cave Police, Lakeway Police and Lake Travis Fire Rescue personnel who will climb the equivalent of 110 stories of the World Trade Center on the 18th anniversary of Sept. 11. Their goal is to pay tribute to the fallen firefighters of that horrific day, so the stair climb is not a timed race event. The parking garage where the tribute takes place is nearest to Dillard's. 7:46 a.m. Sept. 11. Free. Parking Garage A, 12700 Hill Country Blvd., Bee Cave. facebook.com/events/493412727896614

"Holmes and Watson." Austin Playhouse celebrates its 20th anniversary season by revisiting two beloved characters. In this production, John Watson receives a telegram three years after Sherlock Holmes went over a waterfall with his nemesis, Professor Moriarty, that suggests Holmes might not really be dead after all. Watson is compelled to investigate. 8 p.m. Thursday-Saturday, 5 p.m. Sunday through Sept. 29, with additional 2 p.m. matinees Sept. 21 and 28. $17-$34. 6001 Airport Blvd. austinplayhouse.com

Red Dot Art Spree at Women and Their Work. Are you an art enthusiast looking to add to your collection? The Red Dot Art Spree benefit is your chance, as it will feature more than 150 works by some of the best contemporary artists in Texas and beyond. The pieces, in a range of mediums, are priced at $750 and below; all shopping at the event is tax-free. There will be a silent auction, too, with deals ranging from travel getaways to gift certificates to some of Austin's hottest places. 7 to 10 p.m. Sept. 12. $125 general admission, $200 VIP pre-spree. 1710 Lavaca St. womenandtheirwork.org